Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases

被引：169

作者：

Pantaleo, G ^{[1
]}

Harari, A ^{[1
]}

机构：

[1] Univ Lausanne, CHU Vaudois, Dept Med, Lab AIDS Immunopathogenesis,Div Immunol & Allergy, CH-1011 Lausanne, Switzerland

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 05期

关键词：

D O I：

10.1038/nri1840

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

At present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.

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页码：417 / 423

页数：7

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