Lifelong persistence of AML associated MLL partial tandem duplications (MLL-PTD) in healthy adults

被引：12

作者：

Baesecke, Joerg

Podleschny, Martina

Clemens, Robert

Schnittger, Susanne

Viereck, Volker

Truemper, Lorenz

Griesinger, Frank

机构：

[1] Univ Gottingen, Dept Hematol & Oncol, D-37075 Gottingen, Germany

[2] Univ Munich, Klinikum Grosshadern, Med Klin 3, D-8000 Munich, Germany

[3] Univ Gottingen, Dept Gynecol & Obstet, D-37075 Gottingen, Germany

来源：

LEUKEMIA RESEARCH | 2006年 / 30卷 / 09期

关键词：

MLL-PTD; cord blood; healthy newborn; leukemogenesis;

D O I：

10.1016/j.leukres.2006.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

AML-associated MLL-PTD contribute to leukemogenesis by a gain of function and confer an unfavorable prognosis. Like other leukemia associated aberrations they are also present in healthy adults. To delineate the leukemogenic mechanism we tracked down MLL-PTD in normal hematopoiesis and investigated cord blood samples. MLL-PTD were observed in 56/60 (93%) of all cord bloods. In contrast to AML, the transcript frequency in cord blood was four log scales lower as determined by real-time PCR. The CD34+ progenitor cell, CD33+ myeloid, CD19+ B-lymphoid and CD3+ T-lymphoid subfractions were positive. The ubiquitous presence of MLL-PTD in cord blood implicates a lifelong exposure, not an accumulation during lifetime. Since also present in the stem cell subtraction, these factors seem not to be major determinants in MLL-PTD leukemogenesis. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1091 / 1096

页数：6

共 27 条

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