Long-lasting protective immunity against rodent malaria parasite infection at the blood stage by recombinant BCG secreting merozoite surface protein-1

被引：20

作者：

Matsumoto, S

Yukitake, H

Kanbara, H

Yamada, T

机构：

[1] Nagasaki Univ, Sch Dent, Nagasaki 8528588, Japan

[2] Inst Trop Med, Dept Protozool, Nagasaki 8528588, Japan

来源：

VACCINE | 1999年 / 18卷 / 9-10期

关键词：

malaria vaccine; secretion system;

D O I：

10.1016/S0264-410X(99)00326-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previously, we constructed a recombinant live BCG (rBCG) secreting a 15 kDa C-terminal region of MSP-1 from Plasmodium yoelii (MSP-1(15)) and succeeded in the induction of more efficient protective immunity against parasite infection than observed with artificial adjuvants (Matsumoto S, Yukitake H, Kanbara H, Yamada T. Recombinant Mycobacterium bovis bacillus Calmette-Guerin secreting merozoite surface protein 1 (MSP-1) induces protection against rodent malaria parasite infection depending on MSP-1-stimulated interferon gamma and parasite-specific antibodies. J Exp Med 1998;188:845-54 [1]). In this study, we examined the endurance of the protective effects. The protective effect generated by rBCGMSP-1(15) was observed even 9 months after final immunization, whereas the effects of immunization by MSP-1(15) together with incomplete Freund adjuvant (IFA) were found to last only 4 months. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：832 / 834

页数：3

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