8-methoxyquinolines as PDE4 inhibitors

被引：25

作者：

Billah, M

Buckley, GM

Cooper, N

Dyke, HJ

Egan, R

Ganguly, A

Gowers, L

Haughan, AF

Kendall, HJ

Lowe, C

Minnicozzi, M

Montana, JG

Oxford, J

Peake, JC

Picken, CL

Piwinski, JJ

Naylor, R

Sabin, V

Shih, NY

Warneck, JBH

机构：

[1] Celltech Grp Plc, Cambridge CB1 6GS, England

[2] Univ Bradford, Dept Pharmacol, Bradford BD7 1DP, W Yorkshire, England

[3] Schering Plough Corp, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00224-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1617 / 1619

页数：3

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