A novel solid support for synthesis of 3'-phosphorylated chimeric oligonucleotides containing internucleosidic methyl phosphotriester and methylphosphonate linkages

被引：17

作者：

Guzaev, A

Lonnberg, H

机构：

[1] Department of Chemistry, University of Turku

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(97)00739-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability of the method is demonstrated by preparation of 3'-phosphorylated chimeric oligonucleotides containing methyl phosphotriester and methyl phosphonate internucleosidic linkages. (C) 1997 Elsevier Science Ltd.

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页码：3989 / 3992

页数：4

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