Enantioselective addition of diethylzinc to aldehydes with novel chiral C2-symmetric dimeric ligands

被引：18

作者：

Okaniwa, M ^{[1
]}

Yanada, R ^{[1
]}

Ibuka, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 07期

关键词：

aldehyde; alkylation; organozinc; enantioselective; C-2-symmetric 2,2 '-ethylenediiminodiethanol derivatives;

D O I：

10.1016/S0040-4039(99)02230-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel (S)-valinol-based chiral C-2-2,2'-ethylenediiminodiethanol derivatives 4a and 4b have been synthesized and used as chiral catalysts in the enantioselective addition of diethylzinc to aldehydes. (R)-1-Phenylpropanol has been obtained in up to 91% enantiomeric excess. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1047 / 1050

页数：4

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