Genomic organization of the human bone morphogenetic protein-4 gene: Molecular basis for multiple transcripts

被引：26

作者：

vandenWijngaard, A ^{[1
]}

vanKraay, M ^{[1
]}

vanZoelen, EJJ ^{[1
]}

Olijve, W ^{[1
]}

Boersma, CJC ^{[1
]}

机构：

[1] UNIV NIJMEGEN,CELL BIOL LAB,6525 ED NIJMEGEN,NETHERLANDS

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0312

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the human bone morphogenetic protein-4 (BMP-4) gene has been characterized from a genomic cosmid clone of about 38 kb. The transcriptional unit of the human BMP-4 gene is encoded by 5 exons and spans approximately 7 kb. The exon/intron organization of the human BMP-4 gene is similar to that of the mouse gene, with notable sequence differences in the 5' non-coding exons. The human BMP-4 gene has at least two functional promoters, which are used in a cell type specific manner. This observation is of fundamental relevance for understanding the specific role of BMP-4 in skeletal development and bone remodeling. (C) 1996 Academic Press, Inc.

引用

页码：789 / 794

页数：6

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