CLONING AND SEQUENCE OF BONE MORPHOGENETIC PROTEIN-4 (BMP-4) FROM A HUMAN PLACENTAL CDNA LIBRARY

被引：12

作者：

OIDA, S

IIMURA, T

MARUOKA, Y

TAKEDA, K

SASAKI, S

机构：

[1] TOKYO MED & DENT UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG 2,BUNKYO KU,TOKYO 113,JAPAN

[2] TOKYO MED & DENT UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG 1,BUNKYO KU,TOKYO 113,JAPAN

来源：

DNA SEQUENCE | 1995年 / 5卷 / 05期

关键词：

BONE MORPHOGENETIC PROTEIN-4 (BMP-4); CDNA SEQUENCE;

D O I：

10.3109/10425179509030980

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A cDNA clone encoding bone morphogenetic protein-4 (BMP-4) has been,isolated from a human placental cDNA library. Sequence analysis of this clone revealed that the nucleotide sequence of 5' region was different from that of human osteosarcoma BMP-4 and the deduced amino acid sequence indicated deletion of N-terminal 6 amino acids. We confirmed the expression of this type of BMP-4 mRNA in one human osteogenic cell line in addition to the placenta by the polymerase chain reaction (PCR).

引用

页码：273 / 275

页数：3

共 12 条

[1]

CHEN D, 1993, BIOCHIM BIOPHYS ACTA, V1174, P286

[2]

DALE L, 1992, DEVELOPMENT, V115, P573

[3] BONE-INDUCING ACTIVITY OF MATURE BMP-2B PRODUCED FROM A HYBRID BMP-2A/2B PRECURSOR [J].