Prevention of graft rejection and graft-versus-host reaction by a novel immunosuppressant, FTY720, in rat small bowel transplantation

被引：39

作者：

Mitsusada, M ^{[1
]}

Suzuki, S ^{[1
]}

Kobayashi, E ^{[1
]}

Enosawa, S ^{[1
]}

Kakefuda, T ^{[1
]}

Miyata, M ^{[1
]}

机构：

[1] NATL CHILDRENS MED RES CTR,DEPT EXPT SURG & BIOENGN,SETAGAYA KU,TOKYO 154,JAPAN

来源：

TRANSPLANT INTERNATIONAL | 1997年 / 10卷 / 05期

关键词：

immunosuppression; FTY; 720; rat; small bowel transplantation;

D O I：

10.1111/j.1432-2277.1997.tb00927.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

In the present study, we examined the immunosuppressive effect of a new drug, FTY 720, on small bowel transplantation (SET) in rats. Grafts from (LEW x BN) F1-to-LEW rats treated with FTY 720 at 0.5 mg/kg from day 0 to 14 post-SET survived significantly longer than untreated grafts. In addition, the administration of FTY 720 combined with cyclosporin (CyA; 5 mg/kg per day) had a synergistic effect on allograft survival. The graft-versus-host reaction (GVHR) that occurred in the LEW-to-F1 rats was markedly reduced after the administration of FTY 720. FTY 720 combined with a low dose of CyA completely abrogated GVHR without any adverse reaction. FTY 720 treatment resulted in a significant decrease in the number of lymphocytes in the peripheral blood and the spleen, but the number of peripheral neutrophils was unchanged. Thus, FTY 720 would appear to be an ideal drug to combine with CyA in order to control the immune reaction after SBT.

引用

页码：343 / 349

页数：7

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