Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity

被引：107

作者：

Colak, Semra ^{[1
]}

Nelson, Christopher F. ^{[1
,2
]}

Nusslein, Klaus ^{[2
]}

Tew, Gregory N. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA

[2] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA

来源：

BIOMACROMOLECULES | 2009年 / 10卷 / 02期

基金：

美国国家科学基金会;

关键词：

OPENING METATHESIS POLYMERIZATION; DE-NOVO DESIGN; ANTIMICROBIAL PEPTIDE MIMICS; BETA-PEPTIDES; NORBORNENE DERIVATIVES; BLOCK-COPOLYMERS; POLYMERS; WATER; OLIGOMERS; AGENTS;

D O I：

10.1021/bm801129y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).

引用

页码：353 / 359

页数：7

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