Aging in the lympho-hematopoietic stem cell compartment

被引：73

作者：

Geiger, Hartmut ^{[1
,2
]}

Rudolph, K. Lenhard ^{[3
]}

机构：

[1] Cincinnati Childrens Hosp, Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA

[2] Univ Ulm, Dept Dermatol & Allerg Dis, D-89091 Ulm, Germany

[3] Univ Ulm, Inst Mol Med, D-89091 Ulm, Germany

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 07期

关键词：

AGE-RELATED-CHANGES; DNA-DAMAGE REPAIR; EARLY B-CELL; LIFE-SPAN; PROGENITOR CELLS; SERIAL TRANSPLANTATION; TELOMERE DYSFUNCTION; INNATE IMMUNITY; SIDE POPULATION; DEFICIENT MICE;

D O I：

10.1016/j.it.2009.03.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cells of the immune system are progeny of a single primitive cell type, the hematopoietic stem cell (HSC). Aging in most strains of mice is associated with a reduction in HSC frequency and a reduction in HSC function. Aged HSCs demonstrate reduced differentiation toward the lymphoid lineage, and this might be a relevant factor influencing immunosenescence. The molecular mechanisms of HSC aging need to be determined in more detail, but current studies have identified, among others, a role for telomere dysfunction in inducing cell intrinsic checkpoints and environmental alterations, which both skews and reduces stem cell differentiation and function. Reverting or ameliorating aging of HSCs might be a crucial step to restoring immuno-competence in the elderly.

引用

页码：360 / 365

页数：6

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