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Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders

被引：105
作者：
Takebayashi, Minoru
Hisaoka, Kazue
Nishida, Akira
Tsuchioka, Mami
Miyoshi, Izuru
Kozuru, Tosirou
Hikasa, Satoshi
Okamoto, Yasumasa
Shinno, Hideto
Morinobu, Shigeru
Yamawaki, Shigeto
机构：
[1] Kure Med Ctr, Inst Clin Res, Kure 7370023, Japan
[2] NHO, Dept Psychiat, Kure Med Ctr, Kure, Japan
[3] Yamaguchi Univ, Sch Med, Dept Neurosci, Yamaguchi, Japan
[4] Hiroshima Univ, Grad Sch Biomed Sci, Div Frontier Med Sci, Dept Psychiat & Neurosci, Hiroshima, Japan
来源：
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2006年 / 9卷 / 05期
关键词：
GDNF; mood disorders; transforming growth factor (TGF); whole blood;
D O I：
10.1017/S1461145705006085
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Recent post-mortem and imaging studies provide evidence for a glial reduction in different brain areas in mood disorders. This study was aimed to test whether glial cell line-derived neurotrophic factor (GDNF), a member of transforming growth factor (TGF)-beta superfamily, in blood levels was associated with mood disorders. We measured GDNF and TGF-beta levels in whole blood in remitted patients with mood disorders [n=56; major depressive disorders (MDD) 39, bipolar disorders (BD) 171 and control subjects (n=56). GDNF and TGF-beta were assayed with the sandwich ELISA method. Total GDNF levels were significantly lower in MDD and in BD than in control subjects (MDD, p=0.0003; BD, p=0.018), while no significant difference in total TGF-beta 1 or total TGF-beta 2 levels was found in these groups. Our study suggests that lower GDNF levels might be involved in the pathophysiology of mood disorders, although this preliminary study has several limitations.
引用
收藏
页码：607 / 612
页数：6
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