Long-term retention of dextran-coated magnetite nanoparticles in the liver and spleen

被引：60

作者：

Lacava, LM

Garcia, VAP

Kückelhaus, S

Azevedo, RB

Sadeghiani, N

Buske, N

Morais, PC

Lacava, ZGM ^{[1
]}

机构：

[1] Univ Brasilia, Dept Genet & Morfol, Inst Ciencias Biol, BR-70910900 Brasilia, DF, Brazil

[2] Berlin Heart AG, D-12247 Berlin, Germany

[3] Univ Brasilia, Inst Fis Nucl Fis Aplicada, BR-70919970 Brasilia, DF, Brazil

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2004年 / 272卷

关键词：

magnetic fluid; magnetite; dextran; biocompatibility; morphology;

D O I：

10.1016/j.jmmm.2003.12.852

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A dextran-coated, magnetite-based magnetic fluid sample (DexMF) was tested through morphological analysis of mice organs. Clusters of magnetic nanoparticles (MNPs) were observed in liver and spleen tissues from I h up to 6 months after DexMF administration. In spite of long-term retention of MNPs, no morphological alterations, including damaged cells, were observed in the analyzed organs. The data suggest that DexMF sample is biocompatible and adequate for further biomedical tests. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：2434 / 2435

页数：2

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