Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders

被引:63
作者
Mercier, Isabelle [1 ,2 ,3 ]
Jasmin, Jean-Francois [1 ,2 ,3 ]
Pavlides, Stephanos [1 ,2 ,3 ]
Minetti, Carlo [1 ]
Flomenberg, Neal [1 ,2 ,3 ]
Pestell, Richard G. [1 ,2 ,3 ]
Frank, Philippe G. [1 ,2 ,3 ]
Sotgia, Federica [1 ,2 ,3 ,4 ,5 ]
Lisanti, Michael P. [1 ,2 ,3 ,4 ,5 ]
机构
[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Canc Biol, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Dept Med Oncol, Philadelphia, PA 19107 USA
[3] Thomas Jefferson Univ, Stem Cell Biol & Regenerat Med Ctr, Philadelphia, PA 19107 USA
[4] Univ Genoa, Muscular & Neurodegenerat Dis Unit, Genoa, Italy
[5] G Gaslini Pediat Inst, Genoa, Italy
关键词
caveolae; caveolins; human disease pathogenesis; mouse animal models; HUMAN BREAST-CANCER; TUMOR MICROVASCULAR PERMEABILITY; ONCOGENICALLY TRANSFORMED-CELLS; GIRDLE MUSCULAR-DYSTROPHY; LATE SODIUM CURRENT; P42/44 MAP KINASE; CAVEOLIN-1-DEFICIENT MICE; IN-VIVO; INSULIN-RESISTANCE; PROSTATE-CANCER;
D O I
10.1038/labinvest.2009.23
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Here we review the clinical and translational implications of the caveolin gene family for understanding the pathogenesis of human diseases, including breast and prostate cancers, pulmonary hypertension, cardiomyopathy, diabetes, and muscular dystrophy. Detailed phenotypic analysis of caveolin knockout mice has served to highlight the crucial role of a caveolin deficiency in the pathogenesis of many human disease processes. Mutations in the human caveolin genes are associated with a number of established genetic disorders (such as breast cancer, lipodystrophy, muscular dystrophy, and cardiomyopathy), making the caveolins important and novel targets for drug development. The implementation of new strategies for caveolin replacement therapy-including caveolin mimetic peptides-is ongoing. Laboratory Investigation (2009) 89, 614-623; doi:10.1038/labinvest.2009.23; published online 30 March 2009
引用
收藏
页码:614 / 623
页数:10
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