Cyclodextrin-modified MEKC for enantioseparation of hexaconazole, penconazole, and myclobutanil

被引：16

作者：

Ibrahim, Wan Aini Wan ^{[1
]}

Hermawan, Dadan ^{[1
]}

Sanagi, M. Marsin ^{[1
]}

Aboul-Enein, Hassan Y. ^{[2
]}

机构：

[1] Univ Teknol Malaysia, SSRG, Dept Chem, Fac Sci, Skudai 81310, Johor, Malaysia

[2] Natl Res Ctr, Dept Pharmaceut & Med Chem, Cairo, Egypt

来源：

JOURNAL OF SEPARATION SCIENCE | 2009年 / 32卷 / 03期

关键词：

Cyclodextrin-modified micellar electrokinetic chromatography Enantioseparation; Hydroxypropyl-gamma-CD; Triazole fungicides; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; SUPERCRITICAL-FLUID CHROMATOGRAPHY; CHIRAL SEPARATION; CAPILLARY-ELECTROPHORESIS; ONLINE PRECONCENTRATION; PHARMACEUTICAL FORMULATIONS; LIQUID-CHROMATOGRAPHY; TRIAZOLE PESTICIDES; DRUGS; ENANTIOMERS;

D O I：

10.1002/jssc.200800512

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A CD-modified micellar EKC (CD-MEKC) method with 2-hydroxypropyl-gamma-CD (HP-gamma-CD) as chiral selector for the enantioseparation of three chiral triazole fungicides, namely hexaconazole, penconazole, and myclobutanil, is reported for the first time. Simultaneous enantioseparation of the three triazole fungicides was successfully achieved using a CD-MEKC system containing 40 mM HP-gamma-CD and 50 mM SDS in 25 mM phosphate buffer (pH 3.0) solution with resolutions (R,) greater than 1.60, peak efficiencies (N) greater than 200000 for all enantiomers and an analysis time within 15 min compared to 36 min as previously reported using sulfated-beta-CD.

引用

页码：466 / 471

页数：6

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