RNA in cancer

被引：812

作者：

Goodall, Gregory J. ^{[1
,2
,3
,4
]}

Wickramasinghe, Vihandha O. ^{[5
,6
]}

机构：

[1] Univ South Australia, Ctr Canc Biol, Adelaide, SA, Australia

[2] SA Pathol, Adelaide, SA, Australia

[3] Univ Adelaide, Dept Med, Adelaide, SA, Australia

[4] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA, Australia

[5] Peter MacCallum Canc Ctr, RNA Biol & Canc Lab, Melbourne, Vic, Australia

[6] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic, Australia

来源：

NATURE REVIEWS CANCER | 2021年 / 21卷 / 01期

基金：

英国医学研究理事会;

关键词：

METHYLTRANSFERASE GENE EZH2; MESSENGER-RNA; CIRCULAR RNAS; BREAST-CANCER; MICRORNA THERAPEUTICS; SOMATIC MUTATIONS; SPLICING FACTORS; PROSTATE-CANCER; SF3B1; MUTATION; MIR-200; FAMILY;

D O I：

10.1038/s41568-020-00306-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

While the processing of mRNA is essential for gene expression, recent findings have highlighted that RNA processing is systematically altered in cancer. Mutations in RNA splicing factor genes and the shortening of 3 ' untranslated regions are widely observed. Moreover, evidence is accumulating that other types of RNAs, including circular RNAs, can contribute to tumorigenesis. In this Review, we highlight how altered processing or activity of coding and non-coding RNAs contributes to cancer. We introduce the regulation of gene expression by coding and non-coding RNA and discuss both established roles (microRNAs and long non-coding RNAs) and emerging roles (selective mRNA processing and circular RNAs) for RNAs, highlighting the potential mechanisms by which these RNA subtypes contribute to cancer. The widespread alteration of coding and non-coding RNA demonstrates that altered RNA biogenesis contributes to multiple hallmarks of cancer. This Review discusses how altered processing or activity of coding and non-coding RNAs contributes to cancer, introducing the regulation of gene expression by coding and non-coding RNA and discussing both established and emerging roles for RNAs in cancer.

引用

页码：22 / 36

页数：15

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