Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8+ T cells and associated with a proliferative response to p24 antigen

被引：29

作者：

de Quiros, JCLB

Shupert, WL

McNeil, AC

Gea-Banacloche, JC

Flanigan, M

Savage, A

Martino, L

Weiskopf, EE

Imamichi, H

Zhang, YM

Adelsburger, J

Stevens, R

Murphy, PM

Zimmerman, PA

Hallahan, CW

Davey, RT

Connors, M

机构：

[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA

[2] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA

[3] Univ Autonoma Madrid, Clin Puerta Hierro, Serv Med Interna 1, Madrid, Spain

[4] Hosp Gen Gregorio Maranon, Microbiol Serv, Madrid, Spain

[5] NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Frederick, MD USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 04期

关键词：

D O I：

10.1128/JVI.74.4.2023-2028.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.

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页码：2023 / 2028

页数：6

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