Chemokine blockade: a new era in the treatment of rheumatoid arthritis?

被引：34

作者：

Haringman, JJ ^{[1
]}

Tak, PP ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Div Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands

来源：

ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 03期

关键词：

chemokines; rheumatoid arthritis; synovial tissue;

D O I：

10.1186/ar1172

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blockade of chemokines or chemokine receptors is emerging as a new potential treatment for various immune-mediated conditions. This review focuses on the therapeutic potential in rheumatoid arthritis, based on studies in animal models and patients. Several knockout models as well as in vivo use of chemokine antagonists are discussed. Review of these data suggests that this approach might lead to novel therapeutic strategies in rheumatoid arthritis and other chronic inflammatory disorders.

引用

页码：93 / 97

页数：5

共 36 条

[31]

2-K

[32] CCR2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen [J].

Tylaska, LA ;

Boring, L ;

Weng, W ;

Aiello, R ;

Charo, IF ;

Rollins, BJ ;

Gladue, RP .

CYTOKINE, 2002, 18 (04) :184-190

[33] RANTES expression and contribution to monocyte chemotaxis in arthritis [J].

Volin, MV ;

Shah, MR ;

Tokuhira, M ;

Haines, GK ;

Woods, JM ;

Koch, AE .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1998, 89 (01) :44-53

[34] Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation [J].

Xie, JH ;

Nomura, N ;

Lu, M ;

Chen, SL ;

Koch, GE ;

Weng, YM ;

Rosa, R ;

Di Salvo, J ;

Mudgett, J ;

Peterson, LB ;

Wicker, LS ;

DeMartino, JA .

JOURNAL OF LEUKOCYTE BIOLOGY, 2003, 73 (06) :771-780

[35]

Yang YF, 2002, EUR J IMMUNOL, V32, P2124, DOI 10.1002/1521-4141(200208)32:8<2124::AID-IMMU2124>3.0.CO

[36]

2-S

← 1 2 3 4 →