Wnt signaling in cancer

被引：2369

作者：

Zhan, T. ^{[1
,2
]}

Rindtorff, N. ^{[1
]}

Boutros, M. ^{[1
,3
]}

机构：

[1] Heidelberg Univ, Fac Med Mannheim, Div Signaling & Funct Genom, Dept Cell & Mol Biol,German Canc Res Ctr DKFZ, Heidelberg, Germany

[2] Heidelberg Univ, Med Fac Mannheim, Dept Internal Med 2, Mannheim, Germany

[3] German Canc Consortium DKTK, Heidelberg, Germany

来源：

ONCOGENE | 2017年 / 36卷 / 11期

关键词：

WNT/BETA-CATENIN PATHWAY; EPITHELIAL-MESENCHYMAL TRANSITION; PLANAR CELL POLARITY; LEUKEMIA STEM-CELLS; BETA-CATENIN; COLORECTAL-CANCER; BREAST-CANCER; CHROMOSOMAL INSTABILITY; PROTEIN STABILIZATION; BINDING PROTEIN;

D O I：

10.1038/onc.2016.304

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.

引用

收藏

页码：1461 / 1473

页数：13

相关论文

共 205 条

[1]

Mitotic Wnt Signaling Promotes Protein Stabilization and Regulates Cell Size [J].

Acebron, Sergio P. ;

Karaulanov, Emil ;

Berger, Birgit S. ;

Huang, Ya-Lin ;

Niehrs, Christof .

MOLECULAR CELL, 2014, 54 (04) :663-674

[2]

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors [J].

Anastas, Jamie N. ;

Kulikauskas, Rima M. ;

Tamir, Tigist ;

Rizos, Helen ;

Long, Georgina V. ;

von Euw, Erika M. ;

Yang, Pei-Tzu ;

Chen, Hsiao-Wang ;

Haydu, Lauren ;

Toroni, Rachel A. ;

Lucero, Olivia M. ;

Chien, Andy J. ;

Moon, Randall T. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (07) :2877-2890

[3]

WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[4]

Andersson T., 2015, MOL CANCER THER, V14, pA116, DOI DOI 10.1158/1535-7163.TARG-15-A116

[5]

Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells [J].

Aoki, K. ;

Aoki, M. ;

Sugai, M. ;

Harada, N. ;

Miyoshi, H. ;

Tsukamoto, T. ;

Mizoshita, T. ;

Tatematsu, M. ;

Seno, H. ;

Chiba, T. ;

Oshima, M. ;

Hsieh, C-L ;

Taketo, M. M. .

ONCOGENE, 2007, 26 (24) :3511-3520

[6]

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response [J].

Azzolin, Luca ;

Panciera, Tito ;

Soligo, Sandra ;

Enzo, Elena ;

Bicciato, Silvio ;

Dupont, Sirio ;

Bresolin, Silvia ;

Frasson, Chiara ;

Basso, Giuseppe ;

Guzzardo, Vincenza ;

Fassina, Ambrogio ;

Cordenonsi, Michelangelo ;

Piccolo, Stefano .

CELL, 2014, 158 (01) :157-170

[7]

Importance of P-cadherin, β-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma [J].

Bachmann, IM ;

Straume, O ;

Puntervoll, HE ;

Kalvenes, MB ;

Akslen, LA .

CLINICAL CANCER RESEARCH, 2005, 11 (24) :8606-8614

[8]

Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells [J].

Bänziger, Carla ;

Soldini, Davide ;

Schuett, Corina ;

Zipperlen, Peder ;

Hausmann, George ;

Basler, Konrad .

CELL, 2006, 125 (03) :509-522

[9]

Crypt stem cells as the cells-of-origin of intestinal cancer [J].

Barker, Nick ;

Ridgway, Rachel A. ;

van Es, Johan H. ;

van de Wetering, Marc ;

Begthel, Harry ;

van den Born, Maaike ;

Danenberg, Esther ;

Clarke, Alan R. ;

Sansom, Owen J. ;

Clevers, Hans .

NATURE, 2009, 457 (7229) :608-U119

[10]

WNT signaling in bone homeostasis and disease: from human mutations to treatments [J].

Baron, Roland ;

Kneissel, Michaela .

NATURE MEDICINE, 2013, 19 (02) :179-192

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