Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene

被引：64

作者：

Chabriat, H

Vahedi, K

Clark, CA

Poupon, C

Ducros, A

Denier, C

Le Bihan, D

Bousser, MG

机构：

[1] Hop Lariboisiere, Serv Neurol, F-75010 Paris, France

[2] CEA, Serv Hosp Frederic Joliot, DRM, F-91406 Orsay, France

[3] Fac Med Necker, INSERM, U25, Paris, France

来源：

NEUROLOGY | 2000年 / 54卷 / 02期

关键词：

MRI; diffusion; hemiplegic; migraine; CACNA1A gene;

D O I：

10.1212/WNL.54.2.510

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a reversible reduction of water diffusion in the brain during a prolonged attack of hemiplegic migraine. The patient had a sporadic mutation of the CACNA1A gene. The diffusion changes were observed in the contralateral hemisphere 3 and 5 weeks after the onset of hemiplegia. These results suggest the occurrence of hemispheric cytotoxic edema during severe attacks of hemiplegic aura. The mechanisms underlying such ultrastructural modifications are unknown but an abnormal release of excitatory amino acids can be hypothesized.

引用

页码：510 / 512

页数：3

共 10 条

[1] Perfusion-weighted imaging defects during spontaneous migrainous aura [J].