eIF2α phosphorylation: A hallmark of immunogenic cell death

被引：64

作者：

Bezu, Lucillia ^{[1
,2
,3
,4
,5
,6
]}

Sauvat, Allan ^{[2
,3
,4
,5
,6
]}

Humeau, Juliette ^{[1
,2
,3
,4
,5
,6
]}

Leduc, Marion ^{[2
,3
,4
,5
,6
]}

Kepp, Oliver ^{[2
,3
,4
,5
,6
]}

Kroemer, Guido ^{[2
,3
,4
,5
,6
,7
,8
,9
]}

机构：

[1] Univ Paris Sud, Fac Med, Le Kremlin Bicetre, France

[2] Metabol & Cell Biol Platforms, Gustave Roussy Canc Campus, Villejuif, France

[3] Ctr Rech Cordeliers, Equipe Labellisee Ligue Natl Canc 11, Paris, France

[4] INSERM, U1138, Equipe Labellisee Ligue Natl Canc, Villejuif, France

[5] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[6] Univ Paris 06, Paris, France

[7] Ctr Clin Invest Biotherapies Canc CICBT 1428, Villejuif, France

[8] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[9] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Stockholm, Sweden

来源：

ONCOIMMUNOLOGY | 2018年 / 7卷 / 06期

关键词：

anthracyclines; cancer; chemotherapy; ER stress; unfolded protein response; CALRETICULIN EXPOSURE; ANTITUMOR IMMUNITY; CANCER; DNA;

D O I：

10.1080/2162402X.2018.1431089

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2 alpha. eIF2 alpha phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

引用

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