Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds

被引：286

作者：

Coulombe, PA ^{[1
]}

Wong, P ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 08期

关键词：

D O I：

10.1038/ncb0804-699

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intermediate filaments are cytoskeletal polymers encoded by a large family of differentially expressed genes that provide crucial structural support in the cytoplasm and nucleus of higher eukaryotes. Perturbation of their function accounts for several genetically determined diseases in which fragile cells cannot sustain mechanical and non-mechanical stresses. Recent studies shed light on how this structural support is modulated to meet the changing needs of cells, and reveal a novel role whereby intermediate filaments influence cell growth and death through dynamic interactions with non-structural proteins.

引用

页码：699 / 706

页数：8

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