Enantioselective addition of organolithium reagents on isoquinoline

被引：52

作者：

Alexakis, A ^{[1
]}

Amiot, F ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0957-4166(02)00531-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

1-methyl-1,2-dihydroisoquinoline and 1-butyl-1,2-dihydroisoquinoline were obtained by enantio selective addition of organolithium reagents on the isoquinoline. (-)-Sparteine was used as an external catalytic chiral ligand and an enantiomeric excess of 57% could be obtained. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2117 / 2122

页数：6

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