Proton T2 relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T

被引：167

作者：

Michaeli, S ^{[1
]}

Garwood, M ^{[1
]}

Zhu, XH ^{[1
]}

DelaBarre, L ^{[1
]}

Andersen, P ^{[1
]}

Adriany, G ^{[1
]}

Merkle, H ^{[1
]}

Ugurbil, K ^{[1
]}

Chen, W ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Radiol, Ctr Magnet Resonance Res, Minneapolis, MN 55455 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2002年 / 47卷 / 04期

关键词：

T-2 relaxation time; high magnetic field; Carr-Purcell spin echo; cerebral metabolites; adiabatic pulse;

D O I：

10.1002/mrm.10135

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Carr-Purcell and Hahn spin-echo (SE) measurements were used to estimate the apparent transverse relaxation time constant (T-2(dagger)) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T-2(dagger) values of proton resonances (water, N-acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T-2(dagger) decay can be substantially reduced using a Carr-Purcell-type SE sequence. (C) 2002 Wiley-Liss, Inc.

引用

页码：629 / 633

页数：5

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