Formation and Characterization of Light-Responsive TEMPO-Oxidized Konjac Glucomannan Microspheres

被引：80

作者：

Chen, Xiaodong ^{[1
]}

Wang, Shanshan ^{[1
]}

Lu, Meiling ^{[1
]}

Chen, Yuying ^{[1
]}

Zhao, Luhai ^{[1
]}

Li, Wei ^{[1
]}

Yuan, Qipeng ^{[1
]}

Norde, Willem ^{[1
,2
]}

Li, Yuan ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

[2] Lab Phys Chem & Colloid Sci, NL-6703 HB Wageningen, Netherlands

来源：

BIOMACROMOLECULES | 2014年 / 15卷 / 06期

基金：

中国国家自然科学基金;

关键词：

EMULSION POLYMERIZATION; CONTROLLED DELIVERY;

D O I：

10.1021/bm500327m

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A light-responsive delivery system has been developed. It consists of gelly microspheres made of TEMPO-oxidized Konjac glucomannan (OKGM) polymers where the carboxyl (COO-) groups are cross-linked via ferric ions (Fe3+) and in which functional ingredients may be incorporated. By irradiation with (simulated) sunlight, the microspheres degrade, thereby releasing the encapsulated component(s). The degree of oxidation (DO) of the OKGM polymers could be well-controlled between 15 and 80%, as confirmed by proton titrations and FT-IR spectroscopy. OKGM of DO 80% was selected to prepare the microspheres because the high COO- content leads to a high density of cross-links, yielding a strong gel. The electrokinetic potential of the OKGM particles increases with increasing pH and decreasing salt concentration. Mossbauer and FT-IR spectroscopy revealed that the cross-links are formed through two modes of COO--Fe3+ coordination, that is, 68.4% by bridging and 31.6% by unidentate binding. Thus, the unique properties of the OKGM microspheres make them potentially applicable as light-controlled biocompatible delivery systems.

引用

页码：2166 / 2171

页数：6

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