Maribavir antagonizes the antiviral action of ganciclovir on human cytomegalovirus

被引：70

作者：

Chou, Sunwen

Marousek, Gail I.

机构：

[1] VA Med Ctr, Med & Res Serv, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Portland, OR USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 10期

关键词：

D O I：

10.1128/AAC.00577-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir antagonized the anti-CMV effect of ganciclovir, increasing the ganciclovir 50% inhibitory concentration against a sensitive strain by up to 13-fold. Antiviral activities of foscarnet and cidofovir were unaffected by maribavir.

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收藏

页码：3470 / 3472

页数：3

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