Liver-type fatty acid-binding protein attenuates renal injury induced by unilateral ureteral obstruction

被引:83
作者
Kamijo-Ikemori, Atsuko
Sugaya, Takeshi
Obama, Ayako
Hiroi, Junya
Miura, Hiroshi
Watanabe, Minoru
Kumai, Toshio
Ohtani-Kaneko, Ritsuko
Hirata, Kazuaki
Kimura, Kenjiro
机构
[1] St Marianna Univ, Sch Med, Div Nephrol & Hypertens, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan
[2] St Marianna Univ, Sch Med, Dept Anat, Kawasaki, Kanagawa 2168511, Japan
[3] St Marianna Univ, Sch Med, Dept Pharmacol, Kawasaki, Kanagawa 2168511, Japan
[4] CMIC Co Ltd, Tokyo, Japan
关键词
D O I
10.2353/ajpath.2006.060131
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Liver-type fatty-acid-binding protein (L-FABP), which has high affinity for long-chain fatty acid oxidation products, may be an effective endogenous antioxidant. To examine the role of L-FABP in tubulointerstitial damage, we used a unilateral ureteral obstruction (UUO) model. We established human L-FABP (hL-FABP) gene transgenic (Tg) mice and compared the tubulointerstitial pathology of the Tg mice (n = 23) with that of the wild-type (WT) mice (n = 23). Mice were sacrificed on days 2, 4, 5, or 7 after UUO. Although mouse L-FABP was not expressed in WT mice, hL-FABP was expressed in the proximal tubules of the Tg mice with UUO (UUO-Tg) and in sham-operated Tg mice. The expression of renal hL-FABP was significantly increased in UUO-Tg compared with sham-operated Tg mice. The number of macrophages (F4/80) infiltrating the interstitium and the level of expression of MCP-1 and MCP-3 were significantly lower in UUO-Tg kidneys compared with UUO-WT kidneys. In UUO-Tg kidneys, the degree of the tubulointerstitial injury and the deposition of type I collagen were significantly lower than that of UUO-WT kidneys. On day 7, lipid peroxidation product accumulated in the UUO-WT kidneys but not in that of UUO-Tg kidneys. In conclusion, renal L-FABP may reduce the oxidative stress in the UUO model, ameliorating tubulointerstitial damage.
引用
收藏
页码:1107 / 1117
页数:11
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