Exclusive detection of the t(11;18)(q21;q21) in extranodal marginal zone B cell lymphomas (MZBL) of MALT type in contrast to other MZBL and extranodal large B cell lymphomas

被引:97
作者
Rosenwald, A
Ott, G
Stilgenbauer, S
Kalla, J
Bredt, M
Katzenberger, T
Greiner, A
Ott, MM
Gawin, B
Döhner, H
Müller-Hermelink, HK
机构
[1] Univ Wurzburg, Inst Pathol, D-97080 Wurzburg, Germany
[2] Univ Heidelberg, Med Klin & Poliklin 5, Heidelberg, Germany
[3] Med Hsch Hannover, Inst Pathol, Hannover, Germany
[4] Theodor Boveri Inst Biowissensch, Wurzburg, Germany
关键词
D O I
10.1016/S0002-9440(10)65499-5
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Extranodal mucosa-associated lymphoid tissue (MALT)-type lymphomas and nodal and splenic marginal zone B cell lymphomas (MZBL) share morphological and immunophenotypic features with marginal zone B cells of reactive lymphoid tissues. Although displaying a similar immunophenotype, recent investigations suggest fundamental genetic differences among these subgroups. To determine the prevalence of the t(11;18) in a larger series of MALT-type lymphomas and to investigate a possible occurrence in other lymphomas, we screened 106 non Hodgkin's lymphomas (NHL) by interphase cytogenetics using yeast artificial chromosome (YAC) probes flanking the breakpoint at 11q21. A signal constellation indicating a disruption in 11q21 and thus pointing to the presence of the t(11;18) was observed in 9 of 33 (27%) low-grade lymphomas of MALT type. The complete absence of t(11;18)-positive cells in 32 primary and secondary extranodal high-grade lymphomas suggests that low-grade lymphomas of MALT type characterized by the t(11;18) are unlikely to transform into high-grade tumors. The absence of tumor cells carrying the t(11;18) in nodal MZBL challenges the assumption that most, if not all, of these tumors represent the nodal manifestation of a so far undetected low-grade lymphoma of MALT type. The t(11;18) was not detected in a single case of 29 splenic MZBL investigated. This observation strengthens the view that splenic MZBL are biologically different from extranodal MZBL of MALT type.
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页码:1817 / 1821
页数:5
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