Neurochemical Effects of Theta Burst Stimulation as Assessed by Magnetic Resonance Spectroscopy

被引：214

作者：

Stagg, C. J. ^{[1
,2
]}

Wylezinska, M. ^{[1
,3
]}

Matthews, P. M. ^{[1
,4
,5
]}

Johansen-Berg, H. ^{[1
]}

Jezzard, P. ^{[1
]}

Rothwell, J. C. ^{[6
]}

Bestmann, S. ^{[6
,7
]}

机构：

[1] Univ Oxford, Ctr Funct Resonance Imaging Brain, Oxford, England

[2] Univ Oxford, Dept Clin Neurol, Oxford, England

[3] Univ London Imperial Coll Sci Technol & Med, Biol Imaging Ctr, Imaging Sci Dept, MRC Clin Sci Ctr, London, England

[4] Univ London Imperial Coll Sci Technol & Med, Dept Clin Neurosci, London, England

[5] Hammersmith Hosp, GSK Clin Imaging Ctr, London, England

[6] UCL, Sobell Dept Movement Neurosci & Movement Disorder, London, England

[7] UCL, Inst Neurol, Wellcome Trust Ctr Neuroimaging, London, England

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2009年 / 101卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

HUMAN MOTOR CORTEX; LONG-TERM POTENTIATION; METABOTROPIC GLUTAMATE RECEPTORS; CORTICAL EXCITABILITY; IN-VIVO; CORTICOSPINAL EXCITABILITY; HORIZONTAL CONNECTIONS; INHIBITORY CIRCUITS; SENSORIMOTOR CORTEX; WATER-SUPPRESSION;

D O I：

10.1152/jn.91060.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stagg CJ, Wylezinska M, Matthews PM, Johansen-Berg H, Jezzard P, Rothwell JC, Bestmann S. Neurochemical effects of theta burst stimulation as assessed by magnetic resonance spectroscopy. J Neurophysiol 101: 2872-2877, 2009. First published April 1, 2009; doi: 10.1152/jn.91060.2008. Continuous theta burst stimulation (cTBS) is a novel transcranial stimulation technique that causes significant inhibition of synaptic transmission for <= 1 h when applied over the primary motor cortex (M1) in humans. Here we use magnetic resonance spectroscopy to define mechanisms mediating this inhibition by noninvasively measuring local changes in the cortical concentrations of gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx). cTBS to the left M1 led to an increase in GABA compared with stimulation at a control site without significant change in Glx. This direct evidence for increased GABAergic interneuronal activity is framed in terms of a new hypothesis regarding mechanisms underlying cTBS.

引用

页码：2872 / 2877

页数：6

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