Photocytotoxicity of water-soluble fullerene derivatives

被引：57

作者：

Irie, K

Nakamura, Y

Ohigashi, H

Tokuyama, H

Yamago, S

Nakamura, E

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN

[2] KYOTO UNIV, DEPT SYNTHET CHEM & BIOL CHEM, KYOTO 606, JAPAN

[3] UNIV TOKYO, SCH SCI, DEPT CHEM, BUNKYO KU, TOKYO 113, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 08期

关键词：

fullerene; pheophorbide a; photocytotoxicity; photodynamic therapy; porphyrin;

D O I：

10.1271/bbb.60.1359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New water-soluble fullerene carboxylic acids (1 and 2) derived from C-60 and C-70 fullerenes, respectively, were examined for photocytotoxicity toward Raji cells (B lymphocyte). These compounds did not show any photocytotoxic effect even at 50 mu M, while pheophorbide alpha showed significant photocytotoxicity at 0.5 mu M. Therefore, fullerene derivatives derived from C-60 and C-70 would not be practical agents for photodynamic therapy.

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页码：1359 / 1361

页数：3

相关论文

共 15 条

[1] SYNTHESIS, PHYSICOCHEMICAL PROPERTIES AND PHOTOCYTOTOXICITY OF 5 NEW DELTA-SUBSTITUTED CHLORIN-E6 DERIVATIVES [J].

ANDO, T ;

IRIE, K ;

KOSHIMIZU, K ;

TAKEMURA, T ;

NISHINO, H ;

IWASHIMA, A ;

NAKAJIMA, S ;

SAKATA, I .

TETRAHEDRON, 1990, 46 (17) :5921-5930

[2] NEW WATER-SOLUBLE PYROPHEOPHORBIDE A DERIVATIVES AS POSSIBLE AGENTS FOR PHOTODYNAMIC THERAPY OF CANCER [J].

ANDO, T ;

SUZUKI, Y ;

GEKA, R ;

IRIE, K ;

KOSHIMIZU, K ;

TAKEMURA, T ;

NAKAJIMA, S ;

SAKATA, I .

TETRAHEDRON LETTERS, 1991, 32 (38) :5107-5110

[3] PHOTOCYTOTOXICITY OF WATER-SOLUBLE METALLOPORPHYRIN DERIVATIVES [J].

ANDO, T ;

IRIE, K ;

KOSHIMIZU, K ;

TAKEMURA, T ;

NISHINO, H ;

IWASHIMA, A ;

TAKEDA, N ;

NAKAJIMA, S ;

SAKATA, I .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1993, 57 (04) :629-633

[4] PHOTOPHYSICAL PROPERTIES OF C60 [J].

ARBOGAST, JW ;

DARMANYAN, AP ;

FOOTE, CS ;

RUBIN, Y ;

DIEDERICH, FN ;

ALVAREZ, MM ;

ANZ, SJ ;

WHETTEN, RL .

JOURNAL OF PHYSICAL CHEMISTRY, 1991, 95 (01) :11-12

[5] PHOTOPHYSICAL PROPERTIES OF C-70 [J].

ARBOGAST, JW ;

FOOTE, CS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (23) :8886-8889

[6]

GOMER CJ, 1989, RADIAT RES, V129, P1

[7] HEMATOPORPHYRIN AND HPD - PHOTOPHYSICS, PHOTOCHEMISTRY AND PHOTOTHERAPY [J].

KESSEL, D .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1984, 39 (06) :851-859

[8] PORPHYRIN PHOTOSENSITIZATION AND PHOTOTHERAPY [J].

MOAN, J .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 43 (06) :681-688

[9] SYNTHESIS AND INVIVO PHOTODYNAMIC ACTIVITY OF SOME BACTERIOCHLORIN DERIVATIVES AGAINST BLADDER-TUMORS IN RODENTS [J].

MORGAN, AR ;

SKALKOS, D ;

GARBO, GM ;

KECK, RW ;

SELMAN, SH .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (07) :2126-2133

[10] PHOTODYNAMIC TOXICITY OF PORPHYRINS AND CHLORINS FOR A HUMAN-TUMOR CELL-LINE - COMBINED LIGHT AND CONCENTRATION DOSE RESPONSES FOR THE RETAINED FRACTION [J].

NOURSE, WL ;

PARKHURST, RM ;

SKINNER, WA ;

JORDAN, RT .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 151 (01) :506-511