Atom transfer radical polymerization with polypeptide initiators:: A general approach to block copolymers of sequence-defined polypeptides and synthetic polymers

被引：107

作者：

Rettig, H

Krause, E

Börner, HG

机构：

[1] Max Planck Inst Colloids & Interfaces, Colloid Dept, D-14424 Potsdam, Germany

[2] Inst Mol Pharmacol, D-13125 Berlin, Germany

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2004年 / 25卷 / 13期

关键词：

atom transfer radical polymerization (ATRP); block copolymers; chimera; controlled polymerization; peptides;

D O I：

10.1002/marc.200400140

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel two-step polymerization strategy allowing the integration of sequence-defined oligopeptides into synthetic polymers has been demonstrated by the successful synthesis of an oligopeptide macroinitiator (SPPS) followed by solution-phase atom transfer radical polymerization (ATRP) initiated by the oligopeptide macroinitiator. The resulting block copolymer exhibited a low M-w/(M) over bar (n) (1.19) and a controllable (M) over bar (n).

引用

页码：1251 / 1256

页数：6

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[21] COPPER(I) CHLORIDE [J].