Angiogenesis inhibitor epoxyquinol A:: Total synthesis and inhibition of transcription factor NF-κB

被引：71

作者：

Li, CM

Bardhan, S

Pace, EA

Liang, MC

Gilmore, TD

Porco, JA ^{[1
]}

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Ctr Streamlined Synth, Boston, MA 02215 USA

[3] Boston Univ, Dept Biol, Boston, MA 02215 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 19期

关键词：

D O I：

10.1021/ol026513n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of the natural product (+)-epoxyquinol A(1) and related epoxyquinoid dimers, employing a cascade oxidation/electrocylization/Diels-Alder dimerization sequence, is reported. In addition, we show that 1 and related molecules inhibit activation of the transcription factor NF-kappaB.

引用

收藏

页码：3267 / 3270

页数：4

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