In vitro aggregation facilitates beta-amyloid peptide-(25-35)-induced amnesia in the rat

被引：119

作者：

Delobette, S ^{[1
]}

Privat, A ^{[1
]}

Maurice, T ^{[1
]}

机构：

[1] ECOLE NATL SUPER CHIM,INSERM,U336,UNITE DEV PLASTICITE & VIEILLISSEMENT SYST NERVEU,F-34296 MONTPELLIER 5,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 319卷 / 01期

关键词：

beta-amyloid peptide-(25-35); amyloid-type amnesia; water-maze test;

D O I：

10.1016/S0014-2999(96)00922-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The beta-amyloid peptide-(25-35) fragment, but not beta-amyloid peptide-(1-28), shares with beta-amyloid protein-(1-42) the ability to self- aggregate and to induce neurotoxicity in vitro. This study examined the induction of amnesia in rats given intracerebroventricularly soluble or aggregated beta-amyloid peptide-(25-35) (5-45 nmol), or beta-amyloid peptide-(1-28) (15 nmol). Memory deficit in the water-maze test, examined 14 days after aggregated beta-amyloid peptide-(25-35) injection, was more pronounced than with soluble beta-amyloid peptide-(25-35). beta-Amyloid peptide-(1-28) only affected retention. These results confirm the direct amnesic properties of beta-amyloid peptides in the rat brain and showed that prior peptide aggregation markedly facilitates the appearance of amnesia.

引用

收藏

页码：1 / 4

页数：4

相关论文

共 16 条

[1] ADMINISTRATION OF AMYLOID BETA-PEPTIDES INTO THE MEDIAL SEPTUM OF RATS DECREASES ACETYLCHOLINE-RELEASE FROM HIPPOCAMPUS IN-VIVO [J].

ABE, E ;

CASAMENTI, F ;

GIOVANNELLI, L ;

SCALI, C ;

PEPEU, G .

BRAIN RESEARCH, 1994, 636 (01) :162-164

[2] A POTENTIAL ROLE FOR APOPTOSIS IN NEURODEGENERATION AND ALZHEIMERS-DISEASE [J].

COTMAN, CW ;

ANDERSON, AJ .

MOLECULAR NEUROBIOLOGY, 1995, 10 (01) :19-45

[3] BILATERAL INJECTIONS OF BETA-A(25-35)+IBO INTO THE HIPPOCAMPUS DISRUPTS ACQUISITION OF SPATIAL-LEARNING IN THE RAT [J].

DORNAN, WA ;

KANG, DE ;

MCCAMPBELL, A ;

KANG, EE .

NEUROREPORT, 1993, 5 (02) :165-168

[4] TOPOGRAPHY OF A BINDING-SITE FOR SMALL AMNESTIC PEPTIDES DEDUCED FROM STRUCTURE-ACTIVITY STUDIES - RELATION TO AMNESTIC EFFECT OF AMYLOID BETA-PROTEIN [J].

FLOOD, JF ;

ROBERTS, E ;

SHERMAN, MA ;

KAPLAN, BE ;

MORLEY, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :380-384

[5] AMNESTIC EFFECTS IN MICE OF 4 SYNTHETIC PEPTIDES HOMOLOGOUS TO AMYLOID BETA-PROTEIN FROM PATIENTS WITH ALZHEIMER-DISEASE [J].

FLOOD, JF ;

MORLEY, JE ;

ROBERTS, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3363-3366

[6] INHIBITORS OF FREE-RADICAL FORMATION FAIL TO ATTENUATE DIRECT BETA-AMYLOID(23-35) PEPTIDE-MEDIATED NEUROTOXICITY IN RAT HIPPOCAMPAL CULTURES [J].

LOCKHART, BP ;

BENICOURT, C ;

JUNIEN, JL ;

PRIVAT, A .

JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 39 (04) :494-505

[7] Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction [J].

Maurice, T ;

Lockhart, BP ;

Privat, A .

BRAIN RESEARCH, 1996, 706 (02) :181-193

[8] EFFECTS OF AN EXOGENOUS BETA-AMYLOID PEPTIDE ON RETENTION FOR SPATIAL-LEARNING [J].

MCDONALD, MP ;

DAHL, EE ;

OVERMIER, JB ;

MANTYH, P ;

CLEARY, J .

BEHAVIORAL AND NEURAL BIOLOGY, 1994, 62 (01) :60-67

[9] BETA-AMYLOID PROTEIN-INDUCED ALZHEIMERS-DISEASE ANIMAL-MODEL [J].

NITTA, A ;

ITOH, A ;

HASEGAWA, T ;

NABESHIMA, T .

NEUROSCIENCE LETTERS, 1994, 170 (01) :63-66

[10]

PAXINOS G, 1986, RAT BRAIN STEREOTAXI, P156