Magnetic relaxation measurement in immunoassay using high-transition-temperature superconducting quantum interference device system

被引：30

作者：

Yang, H. C. ^{[1
]}

Yang, S. Y.

Fang, G. L.

Huang, W. H.

Liu, C. H.

Liao, S. H.

Horng, H. E.

Hong, Chin-Yih

机构：

[1] Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan

[2] Natl Taiwan Normal Univ, Inst Electroopt Sci & Technol, Taipei 116, Taiwan

[3] Natl Taiwan Normal Univ, Dept Phys, Taipei 116, Taiwan

[4] Da Yeh Univ, Dept Mech & Automat Engn, Changhua 515, Taiwan

来源：

JOURNAL OF APPLIED PHYSICS | 2006年 / 99卷 / 12期

关键词：

D O I：

10.1063/1.2203390

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Due to their ultrahigh sensitivity to magnetic flux, superconducting quantum interference devices (SQUIDs) are able to detect biomagnetic signals. By labeling biotargets with magnetic nanoparticles, several groups have shown that SQUIDs are promising as quantitative probes of biotargets by measuring their magnetic properties. In this work, we describe the design and construction of a high-transition-temperature radio-frequency SQUID magnetometer system for measuring the magnetic relaxation of labeled avidin. We also describe the synthesis of magnetic nanoparticles coated with biotin for use in labeling the avidin. Furthermore, the specifications of the SQUID-based magnetically labeled immunoassay of avidin are explored.

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页数：5

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