Genetic basis of the human epilepsies

被引：17

作者：

Gardiner, RM ^{[1
]}

机构：

[1] Univ London Univ Coll, Dept Paediat, Royal Free & Univ Coll Med Sch, Rayne Inst, London WC1E 6JJ, England

来源：

EPILEPSY RESEARCH | 1999年 / 36卷 / 2-3期

关键词：

epilepsy; genetics; ion channels; potassium channels; sodium channels; acetylcholine receptor;

D O I：

10.1016/S0920-1211(99)00043-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic factors contribute to aetiology in up to 40% of patients with epilepsy. Over 100 single gene Mendelian disorders include epilepsy as one component of what is usually a complex neurological phenotype, but the majority of idiopathic or primary epilepsies display a 'complex' non-Mendelian pattern of inheritance. There have been significant recent advances in understanding the genetic basis of inherited epilepsies at a molecular level. Epilepsy genes fall into several distinct categories including those in which mutations cause abnormal brain development, progressive neurodegeneration, disturbed energy metabolism and abnormal function of ion channels. Ion channel genes involved include those encoding neuronal nicotinic acetylcholine receptor subunits and voltage-gated potassium and sodium channels. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：91 / 95

页数：5

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