Peptide-MHC complexes assembled following multiple pathways: An opportunity for the design of vaccines and therapeutic molecules

被引：7

作者：

Corradin, G

Demotz, S

机构：

[1] Institute of Biochemistry, University of Lausanne, Epalinges

[2] Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges

来源：

HUMAN IMMUNOLOGY | 1997年 / 54卷 / 02期

关键词：

D O I：

10.1016/S0198-8859(97)00080-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Antigen degradation and peptide loading to major histocompatibility complex class I and class II molecules are described with special emphasis on ''noncanonical'' pathways. Examples of specific peptide loading for measles proteins are provided. In addition, characterization of defined epitopes presented to T cells can lead to the design of products of special interest in medicine and, in particular, in development of vaccines. (C) American Society for Histocompatibility and Immunogenetics, 1997.

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页码：137 / 147

页数：11

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