共 13 条
Cutting edge:: The natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression
被引:173
作者:

Ji, HB
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机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA

Liao, GX
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h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA

Faubion, WA
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h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA

Abadía-Molina, AC
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机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA

Cozzo, C
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA

Laroux, FS
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h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA

Caton, A
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h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA

Terhorst, C
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h-index: 0
机构: Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA
机构:
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02215 USA
[2] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
关键词:
D O I:
10.4049/jimmunol.172.10.5823
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
CD4(+)25(+) regulatory T (Treg) cells maintain immunological self-tolerance through mechanisms that are only in part understood. Previous studies suggest that the glucocorticoid-induced TNFR-related protein (GITR), which is preferentially expressed on the surface of Treg cells, potentially provides a signal that abrogates Treg suppression. In this study, we show that a soluble form of mouse GITR ligand (sGITR-L) induces GITR-dependent NF-kappaB activation and blocks in vitro suppression mediated by both resting and preactivated polyclonal and Ag- specific Treg cells. Since sGITR-L along with rIL-2 induces Proliferation of CD4(+)25(+) cells, it appears thats GITR-L can break the anergic state of Treg cells. Because sGITR-L also up-regulates IL-2 secretion by activated CD4(+)25(-) T cells, these two sGITR-L induced signals synergize to interfere with suppressor activity by CD4(+)25(+) Treg cells.
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页码:5823 / 5827
页数:5
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