9-fluorenon-4-carboxamides:: synthesis, conformational analysis, anti-HSV-2, and immunomodulatory evaluation.: Note II

被引：9

作者：

Alcaro, S

Arena, A

Di Bella, R

Neri, S

Ottanà, R

Ortuso, F

Pavone, B

Vigorita, MG ^{[1
]}

机构：

[1] Univ Messina, Dipartimento Farmacochim, Fac Farm, I-98168 Messina, Italy

[2] Univ Catanzaro Magna Graecia, Dipartimento Sci Farmacobiol, I-88021 Roccelletta di Borgia, CZ, Italy

[3] Azienda Osped Univ G Martino, Dipartimento Discipline Chirurg, Unita Microbiol, Fac Med & Chirurg, I-98125 Messina, Italy

来源：

ARKIVOC | 2004年

关键词：

9-fluorenon-4-carboxamides; tilorone analogues; anti-HSV-2; activity; cytokine-inducing properties; conformational analysis;

D O I：

10.3998/ark.5550190.0005.529

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Title 9-fluorenon-4-carboxamides has been prepared as asymmetrically-substituted analogues of the antiviral tilorone and their antiherpetic and cytokine-inducing properties have been explored. The best pharmacological profiles were shown by carboxamides 1, 4, 9, and 10 endowed with anti-HSV-2, IFNalpha, IFNgamma and TNFalpha-inducing properties assayed on peripheral blood mononuclear cells (PBMC). The conformational analysis of compounds 1-10 has been performed by molecular modelling techniques and a geometrical descriptor was evaluated.

引用

页码：334 / 348

页数：15

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