Cerebral plasticity in multiple sclerosis: insights from fMRI

被引：49

作者：

Cifelli, A ^{[1
]}

Matthews, PM ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Dept Clin Neurol, Ctr Funct Magnet Resonance Imaging Brain, Oxford OX3 9DU, England

来源：

MULTIPLE SCLEROSIS | 2002年 / 8卷 / 03期

关键词：

brain; disability; fMRI; multiple sclerosis; recovery;

D O I：

10.1191/1352458502ms820oa

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Functional magnetic resonance imaging (fMRI) allows noninvasive localization of cerebral activation with relatively high spatial and temporal resolution. The considerable potential for the elucidation of the mechanisms of brain function has made it a useful tool to investigate the neural substrate of motor, sensory and cognitive functions. Understanding derived from these basic cognitive neuroscience investigations is beginning to be applied to clinically relevant problems. In this article, applications to multiple sclerosis (MS) are reviewed, which address the challenging notion that adaptive cerebral plasticity may have an important influence on the relationship between MS pathology and its clinical expression.

引用

页码：193 / 199

页数：7

共 51 条

[11]

Dawson J.W., 1916, Trans R Soc Edinb, V50, P517, DOI [10.1007/978-3-319-02735-7, DOI 10.1007/978-3-319-02735-7]

[12]

Evangelou N, 2000, ANN NEUROL, V47, P391, DOI 10.1002/1531-8249(200003)47:3<391::AID-ANA20>3.3.CO

[13]

2-A

[14] Axonal damage in acute multiple sclerosis lesions [J].