Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei

被引：53

作者：

Ogundaini, A ^{[1
]}

Farah, M ^{[1
]}

Perera, P ^{[1
]}

Samuelsson, G ^{[1
]}

Bohlin, L ^{[1
]}

机构：

[1] UNIV UPPSALA, CTR BIOMED, DIV PHARMACOGNOSY, S-75123 UPPSALA, SWEDEN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 06期

关键词：

D O I：

10.1021/np960386k

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new flavano flavanone glycosides, diinsininol (1) and diinsinin (2), have been isolated from the rhizome of Sarcophyte piriei, together with one known flavanone glycoside, naringenin 5-glucoside. Their structures were elucidated on spectroscopic evidence as 5,7,3',4'-tetrahydroxyflavanyl-7-O-beta-glucosyl-(4 beta-8;2 beta-O-7)-eriodictyol (1) and 5,7,3',4'-tetrahydroxyflavanyl-7-O-beta-glucosyl-(4 beta-8;2 beta-O-7)-naringenin (2), respectively. The compounds were tested for their ability to inhibit prostaglandin synthesis, with 1 and 2 giving IC50 values of 9.20 mu M and 13.14 mu M, respectively, and in the inhibition of platelet-activating-factor-induced exocytosis, IC50 values of 49 and 39 mu M.

引用

页码：587 / 590

页数：4