Do eosinophils have a role in the killing of helminth parasites?

被引:238
作者
Meeusen, ENT [1 ]
Balic, A [1 ]
机构
[1] Univ Melbourne, Sch Vet Sci, Ctr Anim Biotechnol, Melbourne, Vic 3010, Australia
来源
PARASITOLOGY TODAY | 2000年 / 16卷 / 03期
关键词
D O I
10.1016/S0169-4758(99)01607-5
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Eosinophils have been shown to be potent effector cells for the killing of helminth parasites in in vitro cultures. However, an in vivo role for eosinophils has been more difficult to establish. Early data showed close associations between eosinophils and damaged or dead parasites in histological sections, and significant correlations between resistance to parasites and the capacity to induce eosinophilia after infection. However, more recent studies, using mice that have reduced or increased eosinophil levels through targeting of the eosinophil-specific cytokine interleukin 5, have not unanimously supported an in vivo role for eosinophils in resistance to parasites. Here, Els Meeusen and Adam Balic review these studies and suggest a major role for the innate immune response in unnatural mouse-parasite models to explain some of the findings. They conclude that the data so far are consistent with a role for eosinophils in the killing of infective larval stages, but not adults, of most helminth parasites.
引用
收藏
页码:95 / 101
页数:7
相关论文
共 50 条
[21]  
KORENAGA M, 1991, IMMUNOLOGY, V72, P502
[22]  
KORENAGA M, 1994, INT J PARASITOL, V24, P951, DOI 10.1016/0020-7519(94)90159-7
[23]  
LANGE AM, 1994, J IMMUNOL, V153, P205
[24]   PARASITES AND COMPLEMENT [J].
LEID, RW .
ADVANCES IN PARASITOLOGY, 1988, 27 :131-168
[25]   TAENIA-TAENIAEFORMIS - EARLY INFLAMMATORY RESPONSE AROUND DEVELOPING METACESTODES IN THE LIVER OF RESISTANT AND SUSCEPTIBLE MICE .2. HISTOCHEMISTRY AND CYTOCHEMISTRY [J].
LETONJA, T ;
HAMMERBERG, C .
JOURNAL OF PARASITOLOGY, 1987, 73 (05) :971-979
[26]   Immunology of helminth infections, with special reference to immunopathology [J].
Meeusen, ENT .
VETERINARY PARASITOLOGY, 1999, 84 (3-4) :259-273
[27]  
Meeusen ENT, 1996, INT J PARASITOL, V26, P813, DOI 10.1016/S0020-7519(96)80046-4
[28]   IMMUNOPATHOLOGY OF GASTROINTESTINAL NEMATODE INFESTATION AND EXPULSION [J].
MILLER, HRP .
CURRENT OPINION IN GASTROENTEROLOGY, 1993, 9 (06) :986-993
[30]  
Ovington KS, 1998, IMMUNOLOGY, V95, P488, DOI 10.1046/j.1365-2567.1998.00620.x