Enzyme assisted enantioselective synthesis of the alkaloid (+)-aloperine

被引：37

作者：

Barilli, A

Belinghieri, F

Passarella, D

Lesma, G

Riva, S

Silvani, A

Danieli, B

机构：

[1] CNR, Ist Chim Riconoscimento, I-20131 Milan, Italy

[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 18期

关键词：

D O I：

10.1016/j.tetasy.2004.06.056

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective synthesis of the lupinine alkaloid (+)-aloperine is described. The synthetic scheme presents three steps that are mediated by enzymes: kinetic resolution, oxidation of a primary alcohol to an aldehyde and oxidation of a secondary alcohol to a ketone. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2921 / 2925

页数：5

共 16 条

[1] Remote stereocenter discrimination in the enzymatic resolution of piperidine-2-ethanol. Short enantioselective synthesis of sedamine and allosedamine [J].