Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging

被引：37

作者：

Biris, Alexandru S. ^{[1
,2
]}

Boldor, Dorin ^{[3
]}

Palmer, Jason ^{[3
]}

Monroe, William T. ^{[3
]}

Mahmood, Meena ^{[2
]}

Dervishi, Enkeleda ^{[2
]}

Xu, Yang ^{[2
]}

Li, Zhongrui ^{[2
]}

Galanzha, Ekaterina I. ^{[1
]}

Zharov, Vladimir P. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Philips Class Laser & Nanomed Labs, Little Rock, AR 72205 USA

[2] Univ Arkansas, Dept Appl Sci, Nanotechnol Ctr, Little Rock, AR 72204 USA

[3] Louisiana State Univ, Ctr Agr, Dept Biol & Agr Engn, Baton Rouge, LA 70803 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2009年 / 14卷 / 02期

关键词：

nanophotothermolysis; nanoparticles; photothermal radiometry; cancer; carbon nanotubes; RAMAN-SPECTROSCOPY; THERAPY;

D O I：

10.1117/1.3119135

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved thermal radiometry imaging for the visualization of laser-induced temperature distribution in multiple-point absorbing targets. The capability of this approach was demonstrated for monitoring of thermal effects under long laser exposure (from millisecond to seconds, wavelength 1064 nm, maximum power 1 W) of cervical cancer HeLa cells labeled with carbon nanotubes in vitro. The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3119135]

引用

页数：6

共 21 条

[1] Interaction of holmium laser radiation and cortical bone: Ablation and thermal damage in a turbid medium [J].