A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease

被引：85

作者：

Cook, Casey ^{[1
]}

Petrucelli, Leonard ^{[1
]}

机构：

[1] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2009年 / 1792卷 / 07期

关键词：

Ubiquitin proteasome system; Parkinson's disease; Alpha-synuclein; Ubiquitin ligase; Substantia nigra; Aggregation; Parkin; Lewy bodies; DJ-1; Leucine-rich repeat kinase 2; ALPHA-SYNUCLEIN AGGREGATION; LEWY BODY DISEASE; ANTIOXIDANT RESPONSIVE ELEMENTS; RECESSIVE JUVENILE PARKINSONISM; TRANSCRIPTION FACTOR NRF2; EARLY-ONSET PARKINSONISM; MITOCHONDRIAL COMPLEX-I; DOPAMINERGIC CELL-DEATH; UNFOLDED PROTEIN STRESS; C-TERMINAL TRUNCATION;

D O I：

10.1016/j.bbadis.2009.01.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed within this review offer new insight and provide direction for future research to conclusively resolve this debate. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：664 / 675

页数：12

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