Noradrenergic receptor sensitivity in obsessive-compulsive disorders .1. Growth hormone response to clonidine stimulation

被引:12
作者
Brambilla, F [1 ]
Perna, G [1 ]
Bellodi, L [1 ]
Arancio, C [1 ]
Bertani, A [1 ]
Perini, G [1 ]
Carraro, C [1 ]
Gava, F [1 ]
机构
[1] UNIV PADUA,CLIN PSICHIAT,PADUA,ITALY
关键词
obsessive-compulsive disorder; alpha-2-adrenoceptors; clonidine; growth hormone-releasing hormone; growth hormone; NEUROENDOCRINE RESPONSES; DEPRESSED-PATIENTS; SEROTONIN; SECRETION; DOPAMINE; RELEASE; RAT; SEX;
D O I
10.1016/S0165-1781(96)03032-6
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
In 15 patients with obsessive-compulsive disorder (OCD) and in 15 healthy controls postsynaptic alpha-2-adrenoceptor sensitivity was examined by measuring the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) and to clonidine stimulation. Basal values of GH and somatomedin-C (SMD-C) and mean GH responses to GHRH were the same in patients and controls, thus suggesting that a peripheral pathology of the somatotropic axis should not be present. GH responses to clonidine stimulation were blunted in patients suggesting that post-synaptic alpha-2-adrenoceptors are subsensitive, possibly due to higher than normal noradrenergic secretion. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码:155 / 162
页数:8
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