Noradrenergic receptor sensitivity in obsessive-compulsive disorders .1. Growth hormone response to clonidine stimulation

被引：12

作者：

Brambilla, F ^{[1
]}

Perna, G ^{[1
]}

Bellodi, L ^{[1
]}

Arancio, C ^{[1
]}

Bertani, A ^{[1
]}

Perini, G ^{[1
]}

Carraro, C ^{[1
]}

Gava, F ^{[1
]}

机构：

[1] UNIV PADUA,CLIN PSICHIAT,PADUA,ITALY

来源：

PSYCHIATRY RESEARCH | 1997年 / 69卷 / 2-3期

关键词：

obsessive-compulsive disorder; alpha-2-adrenoceptors; clonidine; growth hormone-releasing hormone; growth hormone; NEUROENDOCRINE RESPONSES; DEPRESSED-PATIENTS; SEROTONIN; SECRETION; DOPAMINE; RELEASE; RAT; SEX;

D O I：

10.1016/S0165-1781(96)03032-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In 15 patients with obsessive-compulsive disorder (OCD) and in 15 healthy controls postsynaptic alpha-2-adrenoceptor sensitivity was examined by measuring the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) and to clonidine stimulation. Basal values of GH and somatomedin-C (SMD-C) and mean GH responses to GHRH were the same in patients and controls, thus suggesting that a peripheral pathology of the somatotropic axis should not be present. GH responses to clonidine stimulation were blunted in patients suggesting that post-synaptic alpha-2-adrenoceptors are subsensitive, possibly due to higher than normal noradrenergic secretion. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：155 / 162

页数：8

共 42 条

[11] GROWTH-HORMONE AND OTHER RESPONSES TO CLONIDINE IN PATIENTS WITH ENDOGENOUS-DEPRESSION [J].