Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement

被引:59
作者
de Bazelaire, Cedric
Rofsky, Neil M.
Duhamel, Guillaume
Zhang, Jingbo
Michaelson, M. Dror
George, Daniel
Alsop, David C.
机构
[1] Hop St Louis, Dept Radiol, F-75475 Paris 10, France
[2] Beth Israel Deaconess Med Ctr, Dept Radiol, Cambridge, MA USA
[3] Harvard Univ, Sch Med, Cambridge, MA 02138 USA
[4] Massachusetts Gen Hosp, Dept Hematol Oncol, Boston, MA 02114 USA
[5] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA
关键词
dynamic contrast enhancement; T2*; tumor; input function;
D O I
10.1007/s00330-006-0198-1
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This study analyzed the T2* effect of extracellularly distributed gadolinium contrast agents in arterial blood during tumor studies using T1-weighted sequences at high field strength. A saturation-prepared dual echo sequence with echo times of 1.5 and 3.5 ms was employed at 3 T to simultaneously characterize T1 and T2* of arterial blood during bolus administration of Gd-DTPA in 28 patients with body tumors. T2* effect and T1 effect of Gd-DTPA on image intensity of whole blood were calibrated in human blood samples with different concentrations of contrast agent. T2* was used to estimate concentration near the peak of the bolus. T1 was used to measure lower concentrations when T2* was not significant. T2* was measurable on calibration curves for Gd-DTPA concentrations higher than 4 mM. This concentration was exceeded in 18 patients. The mean signal intensity reduction because of T2* effect was estimated at 22 +/- 14% of the T2* compensated signal. Using T2* measurements reduced underestimations of peak arterial Gd-DTPA concentration (59 +/- 38%) and overestimation of permeability K-trans (58%). The T2* effect of gadolinium contrast agents should therefore be accounted for when performing tumors study with T1-weighted sequences at high field strength.
引用
收藏
页码:2083 / 2091
页数:9
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