Advances in understanding neuroendocrine alterations in PTSD and their therapeutic implications

被引:213
作者
Yehuda, Rachel
机构
[1] Mt Sinai Sch Med, Div Traumat Stress Studies, New York, NY 10029 USA
[2] James J Peters Vet Affairs Med Ctr, Bronx, NY 10468 USA
来源
PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS | 2006年 / 1071卷
关键词
posttraumatic stress disorder; cortisol; neuroendocrine alterations; novel therapeutic strategies; hypothalamic-pituitary-adrenal axis;
D O I
10.1196/annals.1364.012
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The findings from investigations of the neuroendocrinology of posttraumatic stress disorder (PTSD) have highlighted alterations that have not historically been associated with pathologic processes, and have, accordingly, raised several questions about the nature of the findings and their relationship to PTSD. The most infamous of these observations-low cortisol levels-has been the subject of much discussion and scrutiny because the finding has been both counterintuitive, and not uniformly reproducible. This fact notwithstanding, novel therapeutic approaches to the treatment of PTSD are in large part predicated on the assumption that glucocorticoid levels may be lower in PTSD. This article summarizes important neuroendocrine observations in cortisol and provides strategies for understanding what has emerged over the past two decades, to be a complex and sometimes contradictory literature.
引用
收藏
页码:137 / 166
页数:30
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