Current findings from prophylactic HPV vaccine trials

被引：107

作者：

Koutsky, Laura A. ^{[1
]}

Harper, Diane M.

机构：

[1] Univ Washington, Dept Epidemiol, Sch Publ Hlth, Seattle, WA 98195 USA

[2] Dartmouth Med Sch, Norris Cotton Canc Ctr, Dept Obstet & Gynecol, Lebanon, NH USA

[3] Dartmouth Med Sch, Norris Cotton Canc Ctr, Dept Community & Family Med, Lebanon, NH USA

来源：

VACCINE | 2006年 / 24卷

关键词：

HPV; prophylactic vaccines; prevention; cervical cancer;

D O I：

10.1016/j.vaccine.2006.06.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Early data from randomized controlled trials consistently show that prophylactic human papillomavirus virus-like particle (HPV VLP) vaccines are effective in preventing infection and lesions caused by the targeted HPV type(s). Two vaccines, a bivalent HPV-16/18 VLP vaccine and a quadrivalent HPV-6/11/16/18 VLP vaccine, are currently undergoing evaluation in phase III trials with anticipation of receiving regulatory approval for use in immunization programs worldwide. Both vaccines have the potential to substantially reduce HPV-related morbidity and mortality. This review focuses on published data from clinical trials of these two vaccines. (c) 2006 Published by Elsevier Ltd.

引用

页码：114 / 121

页数：8

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