Towards whole-organ modelling of tumour growth

被引：86

作者：

Alarcón, T

Byrne, HM

Maini, PK

机构：

[1] Univ Nottingham, Sch Math Sci, Div Appl Math, Ctr Math Med, Nottingham NG7 2RD, England

[2] Univ Oxford, Inst Math, Ctr Math Biol, Oxford OX1 3LB, England

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2004年 / 85卷 / 2-3期

关键词：

cancer; vascular networks; blood flow heterogeneity; cell cycle; p27;

D O I：

10.1016/j.pbiomolbio.2004.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：451 / 472

页数：22

共 59 条

[51]

Rothman DH, 2004, Lattice-gas cellular automata: Simple models of complex hydrodynamics

[52]

Royds JA, 1998, J CLIN PATHOL-MOL PA, V51, P55

[53] Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling [J].